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This pathway is influenced by peripheral dopamine activity, as coincubation of dopamine, a GLP-1RA, and a dopamine D2 receptor antagonist increases AMPK phosphorylation and subsequent activation of thermogenesis, likely through a dopamine D1-receptor-mediated mechanism [115]

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The insulin-sensitizing effects of tirzepatide may be beneficial for PCOS, but individual responses vary, and limited direct evidence exists for tirzepatide specifically in PCOS populations