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Quick Answer: The most common side effects of tirzepatide are gastrointestinal symptoms including nausea (12-30%), diarrhea (13-24%), vomiting (6-12%), and constipation (6-17%), which typically diminish over time with gradual dose titration

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This dysbiosis is temporary and typically self-corrects as your gut microbiota rebalances over time

Stop if symptoms worsen

Acute kidney injury: diarrhea, nausea, and vomiting may lead to dehydration which may cause kidney problems such as acute kidney injury and, in rare cases, requiring hemodialysis
