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Collectively, these axes establish an integrated pathophysiological framework linking microbiota disturbances to the progression of T2D and the progressive loss of -cell function

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Multiple dietary compounds have shown to be powerful agonists of GPR120, such as pinolenic acid, a poly-unsaturated fatty acid (C18:3 trans, cis, cis 5, 9, 12) found in pine nut oil (277), or the yeast derived phytosphingosine (278)

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