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Mice were habituated in custom built behavior boxes equipped with a running wheel in a 12/12 light cycle for 10 days and fed ad libitum water, high fat diet (HFD, Research Diets D12492i) and regular chow (Labdiet Picolab 5053) in separate hoppers

If pregnancy is a possibility for you, you should discuss birth control options with your healthcare team

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Understanding how GLP-1 agonists are transforming diabetes treatment and pharmacotherapy for obesity is essential for industry stakeholders

The robust triglyceride reduction seen at higher retatrutide doses is attributed to the glucagon receptor pathways direct stimulation of hepatic fat oxidation, which reduces hepatic VLDL secretion and subsequently lowers circulating triglyceride concentrations