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HFpEF is often accompanied by excess fat around the heart, called epicardial adipose tissue (EAT)

A proportion of participants also discontinued GLP-1 RA therapy after 3 years and it is well described that individuals can re-gain two-thirds of their initial weight loss upon cessation of GLP-1 RA [44]

It also discusses the benefits of natural compounds that modulate GLP-1 and highlights the importance of finding alternatives to injectable GLP-1 receptor agonists (GLP-1RAs)

This still requires further assessment, said Camilleri, who noted that so far, the data show only a very small increased risk of gastroparesis

In this regard, we recommend using a composite endpoint of both the number of daily bowel movements and the number of stools of type 6 or 7 on the Bristol stool form scale