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This creates an uncomfortable reality: if lipotoxicity and insulin resistance are removed early, many late-stage antifibrotic strategies become clinically and economically marginal

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However, studies have found that use of these drugs can lead to an increased risk of serious injuries such as stomach paralysis and intestinal blockage

Monitoring fasting insulin, HbA1c, and fasting glucose provides insight

It has been discussed in other papers whether to include active, total or both depending on the situation