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Description

We summarize here the similarities and differences of these two incretin hormones in secretion and metabolism, their insulinotropic action on pancreatic cells, and their noninsulinotropic effects, and discuss their potential in treatment of type 2 diabetes

Patients should seek urgent medical attention if they experience severe persistent abdominal pain (which may indicate pancreatitis), persistent vomiting/dehydration, jaundice, acute visual changes, or hypoglycaemia if on insulin or sulfonylureas

Endocrinology 1993

usually improves over several weeks Diarrhoea or constipation : Altered bowel habits due to delayed gastric emptying Abdominal discomfort : Bloating, dyspepsia, or gastro-oesophageal reflux symptoms Practical management strategies recommended by NICE and specialist diabetes services include: Starting at the lowest licensed dose and titrating gradually according to the product's summary of product characteristics Eating smaller, more frequent meals and avoiding high-fat foods Maintaining adequate hydration, particularly if experiencing vomiting or diarrhoea Taking the injection at a consistent time as specified in the SmPC for your particular medication Less common but important adverse effects include: Injection site reactions : Rotate injection sites systematically between abdomen, thigh, and upper arm to minimise localised reactions Hypoglycaemia : Risk increases when GLP-1 agents are combined with insulin or sulphonylureas