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This supports expanding its use to all overweight or obese patients with atherosclerotic cardiovascular disease, revising BMI-based prescription limits to focus on reducing cardiovascular risk, and positioning GLP-1RAs as an important part of secondary prevention for heart disease

GLP-1 and energy balance: An integrated model of short-term and long-term control

PlexusDx Personalized Solutions to Prevent Weight Regain PlexusDx addresses weight regain through three precision strategies: (1) genetic testing to confirm semaglutide is the right choice for your biology, (2) flat-rate dosing that makes dose optimization affordable, and (3) ongoing protocol review to catch tolerance early

While positive psychological effects accompany weight loss regardless of dietary strategy [181,182], promising studies from the emerging field of metabolic psychiatry suggest that the ketogenic diet may offer unique brain health benefits unrelated to weight loss such as reduced neuroinflammation, reduced oxidative stress, and improved brain energy production [183,184,185,186,187]

The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest