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April 8, 2025

Retatrutide targets three receptors (GIP, GLP-1, and glucagon) compared to two for tirzepatide (GIP and GLP-1) and one for semaglutide (GLP-1)

Coverage expectations are rising, job decisions are being shaped by benefit offerings, and workplace culture around weight loss is overdue for a rethink

These medications mimic or enhance the action of natural incretins and are prescribed for type 2 diabetes management and, in some cases, weight management

Therefore, comprehensive clinical trials are needed to establish clear guidelines on the combined use of GLP-1RAs and osteoporosis treatments
