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In contrast, a multicenter retrospective cohort study, including a higher-risk population (23% with CKD) reported slower eGFR decline and lower risks of CKD progression and doubling of serum creatinine among SGLT2 inhibitor users compared with GLP-1 receptor agonist users

Rachit Agrawal To view or add a comment, sign in Hydromorphone Potent Opioid Analgesic Hydromorphone is a semisynthetic opioid used for the management of moderate to severe pain when other analgesics are insufficient

They may also reduce absorption of certain medications if taken simultaneously

Garvey WT, Birkenfeld AL, Dicker D, Mingrone G, Pedersen SD, Satylganova A, et al

Future studies whenever feasible might continue to explore heterogeneity of treatment effects of GLP1 receptor agonists or SGLT2 inhibitors, especially in clinically relevant subgroups, across BMI strata, and across age strata, which may suggest opportunities to optimize personalized dementia risk mitigation based on risk profiles