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(2023, November 8)
[PubMed] [Google Scholar] 6
Subtle conformational dynamics allow the C-terminus of GLP-1 to access the ECD binding site, and the ligand binding triggers further dissociation of the ECD from the TMD allowing the N-terminus of GLP-1 to enter the orthosteric pocket in the TMD and activate the receptor
This is because your doctor may stop treatment if weight loss is not achieved
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