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GIP promotes -cell proliferation by activating the Raf-Mek1/2-ERK1/2 signaling pathway via cAMP/PKA/Rap1 [87] and inducing the transcription of the cyclin D1 gene, an important regulator of the cell cycle, via multiple signaling pathways [88]

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Conversely, those avoiding HRT may rely more heavily on semaglutide's glucose-stabilizing properties to manage insulin resistance and appetite

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