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Xingye D, Wenhao HZ, Qing Z, Wei W, Gaoren W, Jiaxiang G, Xiaobin B, Yunqing G, Xuefeng Z, Jiaye J, Yaozeng G

By simultaneously activating GLP-1, GIP, and glucagon receptors, it allows researchers to investigate receptor cross-talk, intracellular cascades, and their role in glucose regulation, lipid metabolism, and energy homeostasis

Preclinical studies have shown that large doses of GLP-1RAs can reduce lipid deposition and plaque volume on the aortic surface of hyperglycemic mice via an AMPK-independent action in streptozotocin (STZ)-induced hyperglycemic and hyperlipidemic mice or type 1 diabetic rats [55]

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