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RNA-seq and experimental results revealed that hepatic Serpina3c expression was consistently reduced in PPE offspring before and after birth, which led to an increase in chymase-Ang II production and subsequent activation of its receptor AT1R, leading to MASLD susceptibility

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The findings will likely change the standard of care, as this Cancer Currents post explains.

Taking ibuprofen while on Mounjaro requires careful attention because tirzepatide affects stomach function and NSAIDs carry gastrointestinal risks
