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A recent multicentre placebo-controlled trial of liraglutide efficacy in adolescents and children with PWS without diabetes showed that although adolescents treated with liraglutide 3 mg had lower hyperphagia scores at week 52, changes in BMI standard deviation score from baseline to week 16 and week 52 did not significantly differ (38)

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The estimated 24-hour urinary output for patients on dulaglutide was lower compared with placebo: 3591 mL (95% CI: 2922, 4260) versus 4534 mL (95% CI: 3865, 5203), with an estimated mean difference of 943 mL (95% CI: 1473, 413