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Who Should Avoid This Combination: Safety and Contraindication Screening Patients with a history of cardiovascular disease, uncontrolled hypertension, arrhythmias, or coronary artery disease should not combine semaglutide with phentermine without extensive cardiologic evaluation

Patients using Semaglutide GLP-1 often experience greater weight loss compared to those on placebo, with some studies reporting up to 15% reduction in body weight

Weight Loss Goals: Your desired weight loss goals and timeline can influence your choice

There are also more serious side effects that can occur, though they are less common

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