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Clinical scenarios and decision-making framework Different patient situations call for different approaches

The best approach is physician-guided, patient-specific, and focused on the whole metabolic picture

This method includes several metrics for cross-validation to enhance the robustness of signal detection and minimize false positives, such as the reporting odds ratio (ROR), proportional reporting ratio (PRR), empirical Bayes geometric mean (EBGM), and Bayesian confidence propagation neural network (BCPNN)

They are also looking at various mouse models of inflammation, including heart disease, atherosclerosis, and liver and kidney inflammation, to establish whether the beneficial effects of GLP-1 in each case are indeed mediated through the brain

Search string: (Glucagon-Like Peptide-1 Receptor Agonist* OR GLP-1-RA* OR GLP-1-R* OR GLP-1 Receptor Agonist* OR Liraglutide OR Semaglutide OR Tirzepatide OR Exenatide OR Exendin-4) AND (Stem Cells[Mesh] OR stem cell* OR stromal cell* OR adult progenitor cell* OR hASC OR hASCs OR ASC OR ASCs OR adipose-derived stem cell* OR ADSC* OR MSC OR mesenchymal stem cell* OR mesenchymal stromal cell* OR mesenchymal progenitor cell* OR bone-marrow derived mesenchymal stem cell* OR BD-MSC* OR umbilical cord tissue derived mesenchymal stem cell* OR UC-MSC*) The date of the search was June 30th, 2025