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As the body adjusts to the medication, some people report feeling more tired than usual, especially as appetite suppression sets in

Safety and tolerability were assessed throughout the study by monitoring adverse events (AEs), clinical laboratory tests, and physical examinations

Five years ago, the Grammy-nominated artist weighed over 520 pounds, adding that it was the maximum number the scale he used could reach, he told Men's Health

In ATTAIN-2 , which specifically studied people with both obesity and type 2 diabetes (a group for whom weight loss is known to be harder), participants on the highest dose lost an average of 10.5% of body weight (about 23 lbs) over 72 weeks, while also reducing A1C by an average of 1.8%

At the time, the finding seemed interesting but not especially groundbreaking