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In the duodenum, pancreatic enzymes cleave B12 from R-proteins, allowing binding to intrinsic factor produced by gastric parietal cells

Based on the GLP-1 and GIP receptors it targets, the expected effects are the same gastrointestinal package as the rest of the class: nausea, vomiting, constipation, and less appetite, worst while the dose is climbing

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Approximately 55% of children with obesity continue to have obesity in adolescence, and about 80% of adolescents with obesity remain affected by it in adulthood

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