glp 1 drugs vs metformin Synergistic effects of with liraglutide against endothelial dysfunction through GLP-1 receptor and PKA signalling pathway 7 Surprising Benefits of Metformin
Description
At the tissue level, GLP-1 agonists diminish ectopic fat accumulation in the liver and muscle, enhancing insulin sensitivity
However, the mean receptor occupancy value for the GCGR at the same dose was 11.2 (14.4)% only, indicating no clear occupancy of the GCGR in the liver by SAR425899 in this study
This class may help weight loss in obesity and reduce non-alcoholic fatty liver disease (NAFLD) so may provide additional treatment options in diabetic patients with these issues
(2023) 381:eadd5787
Scheen AJ, Delanaye P
