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Surrogate endpoints and health technology assessment: a review of methodological considerations

These effects can be beneficial for patients with type 2 diabetes who are struggling to manage their blood sugar levels

Staying hydrated, eating smaller meals, and adding dietary fiber support tolerability

The work was also in part supported by the Charles B

However, big pharma will still have the ability to charge premium prices for innovator molecules, especially those with higher efficacy (eg retatrutide) and those aimed at niche patient populations rather than the mass market (eg survodutide, which is targeting MASH endpoints in clinical trials)