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This is the most likely medium-term solution to drive down the costs of GLP-1 drugs and eliminate the drug shortages in the marketplace.

4.2 Combination therapy strategies Combining triple receptor agonists with other pharmacological agents holds promise for synergistic metabolic benefits in MASLD management

For example, Nagashima and colleagues showed that administration of active GLP-1(736) amide via osmotic minipumps for 4 weeks decreased atherosclerotic lesions and macrophage numbers in the aortic wall in Apoe / mice on high-fat diet (HFD), compared with vehicle controls (1)

aspartate aminotransferase (AST/SGOT)

The Tinsley & Nadolsky case series suggests the principle extends to current-generation GLP-1s when patients implement structured resistance training and meet protein targets