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In the Syrian golden hamster ICV injections of exendin 939 into the third ventricle acutely depressed postprandial TRL-TG and ApoB48 secretion by approximately 55 %
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Despite improved glycemic control, DPP-4 inhibitors and basal insulin failed to reduce CV risk in T2DM patients [64-67], while GLP-1 RAs, SGLT2 inhibitors, and pioglitazone significantly reduce both plasma glucose concentration and CV risk (3-point MACE)
