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Synthetic human GLP-1 administered into the jugular vein of male rats acutely increased systolic and diastolic BP, as well as HR, which returned to basal levels 25 min after GLP-1 administration

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A: GLP-1 receptor agonist medications have undergone extensive clinical testing and are FDA-approved for use in adults with obesity

Remember, tirzepatide works best when combined with a healthy diet, regular physical activity, adequate rest, and periodic consultations with your provider

For example, capsaicin treatment, which destroys some vagal afferents, abolishes the suppressive effect of low levels of GLP-1 administration (6 and 120 pmol/kg) 135