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Its main modification is a C16 palmitoyl moiety covalently attached to the lysine at position 20 through a -glutamic acid chemical spacer

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While we often focus on losing this fat for health and aesthetic reasons, it serves a critical biological purpose: insulation

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GLP-1 secretion in response to dietary lipids In addition to sensing carbohydrates and glucose, L-cells, like other enteroendocrine cells, sense dietary lipids and protein (see next section) through specific cell-surface receptors, which bind metabolites of the dietary lipids and proteins [285] (Figure 4)