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The mechanisms underlying this loss may therefore have causal implications in the pathogenesis of disease

PPG neurons display axonal inputs with the most GLP-1R-expressing brain regions and can be activated by the GLP-1 originating from those cells (McLean et al., 2021)

The STEP 1 trial, for example, found that the average weight loss over 68 weeks was 14.9%

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I will not adjust my medications up or down without prior instruction to do so
