retatrutide turkey ESC 2024: improves lipid and cardiovascular risk profile in Phase II trial Retatrutide (LY3437943) | GCGR/GLP-1R/GIPR Agonist

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6 However, GLP-1 receptor agonists and gut-derived GLP-1 do not cross the bloodbrain barrier and cannot access GLP-1 receptors in the brain parenchyma, which can only be accessed by brain (pre-proglucagon neuron)-derived GLP-1

For example, emerging research on GLP-1 receptor agonistssuch as liraglutide and semaglutidehas already demonstrated promising cognitive improvements, enhanced memory, and protection against neurodegenerative changes

Combined with peptide-induced gastric slowing, they can trigger pronounced nausea

Interestingly, GLP-1(2836) amide, a metabolite that does not bind to GLP-1R, was found to protect against cardiac injury in mice after LAD artery ligation by a mechanism involving mitochondrial trifunctional protein- (MTP) and intracellular soluble adenylyl cyclase (sAC) in cardiac smooth muscle and endothelial cells, but not cardiomyocytes (24)