glp-1 receptor agonists should be avoided in patients with Frontiers Understanding GLP-1 receptor agonists and
Description
As noted by others (Khan et al., 2020), it remains to be clarified if use of GLP-1 RAs is safe across the HF phenotypes

The trial was stopped early for efficacy
[DOI] [PMC free article] [PubMed] [Google Scholar] 13.Rayner C.K., Watson L.E., Phillips L.K., Lange K., Bound M.J., Grivell J., Wu T., Jones K.L., Horowitz M., Ferrannini E., et al

Safety Issues of Tirzepatide (Pancreatitis and Gallbladder or Biliary Disease) in Type 2 Diabetes and Obesity: A Systematic Review and Meta-Analysis

Briefly, FFAs can reduce the tyrosine phosphorylation of insulin receptor substrate-1 by activating the serine/threonine kinase, thereby aggravating IR (151)
