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Description
Sublingual semaglutide , tirzepatide drops , and GLP-1 patches represent additional non-injection delivery methods under development

Cardiovascular Safety : The cardiovascular safety of tirzepatide has been evaluated and confirmed to date through a pre-specified meta-analysis of phase 2 and 3 randomized trials comparing tirzepatide with other placebo, insulin glargine, degludec, semaglutide, dulaglutide for a minimum of 26 weeks (including the GPGB, SURPASS 1,2,3,4,5, and J-mono studies) [67]

Physicians should balance the benefits and potential risks of semaglutide in their clinical decisions [63]

One case report documented a patient who developed gastroparesis after rapid escalation from low-dose to therapeutic-dose semaglutide within weeks rather than following the standard monthly titration

Risk Summary There is no information regarding the presence of JANUMET XR in human milk, the effects on the breastfed infant, or the effects on milk production
