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Table 3 Results of a 52-week Monotherapy Trial in Adults with Type 2 Diabetes Mellitus a Figure 3 Mean HbA 1c for Adult Patients with Type 2 Diabetes Mellitus who Completed the 52-week Trial and for the Last Observation Carried Forward (LOCF, intent-to-treat) data at Week 52 (Monotherapy) Combination Therapy Add-on to Metformin In this 26-week trial, 1,091 adult patients with type 2 diabetes mellitus were randomized to liraglutide injection 0.6 mg, liraglutide injection 1.2 mg, liraglutide injection 1.8 mg, placebo, or glimepiride 4 mg (one-half of the maximal approved dose in the United States), all as add-on to metformin

Proceed with standard GLP-1 initiation

Cellular Resilience: GLP-1s promote autophagy (cellular cleanup) and enhance immune cell function
The activation of this receptor is known to mediate glucose-stimulated insulin secretion and a glucose-independent release of incretin hormones by intestinal enteroendocrine cells (88)

The temporal induction of GST-4::GFP was greater in the sterile mutants compared to WT, consistent with the notion that these mutants harbor elevated levels of lipid, which result in GST-4 induction
