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Despite variability across studies, body composition analyses from clinical trials have shown that a relevant proportion of total weight reduction under GLP-1RAs therapy can be attributed to the loss of lean mass, including skeletal muscle [12]

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Furthermore, GLP-1 receptor agonists induce anti-inflammatory effects that could attenuate the low-grade inflammation that underlies obesity, PsO, and HS (reviewed recently in the context of PsO and psoriatic arthritis).68 Finally, improved metabolic control and cardio-renal protection could be beneficial for reducing CVR and managing comorbidities such as DT2 or metabolic syndrome

Diabetes Metab 2020;46:100109 [DOI] [PubMed] [Google Scholar] 35.Ahmann AJ, Capehorn M, Charpentier G, et al

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