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Gastrointestinal side effects associated with Zepbound, particularly nausea and vomiting, may occasionally trigger autonomic responses including diaphoresis (sweating)

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In the MASLD (metabolic dysfunction-associated steatotic liver disease) substudy, participants on the 12 mg dose achieved greater than 85% liver fat normalization

However, accessibility, affordability, physician supervision, and long-term monitoring remain important considerations for widespread clinical adoption