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At present, this is considered as a local circuit and has only been described in rodents, but knowledge is limited, and it is unclear if it has a role to play in food intake and body weight control or whether this circuit exists in humans

For example, DPP-4 cleaves BNP (132) into BNP (332), which is regularly detected in the plasma of patients with congestive HF [97]

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In conclusion, tirzepatide increased blood pressure and sympathetic activity in hypertensive rats without cardiac protection, highlighting context-dependent cardiovascular actions

wrote the first draft of the manuscript