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Note that with this method of delivery absorption occurs predominantly in the stomach to achieve therapeutic plasma levels, and overcomes otherwise insurmountable challenges of peptide absorption related to solubility, molecular size, and enzymatic degradation in the protease-rich environment of the small intestine (Buckley et al, 2018)

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In chronic pain states, TRPV1 channels are upregulated in nociceptive neurons, which lowers stimulation thresholds and increases pain perception, as reported in hyperalgesia or allodynia 21