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Baseline markers may include: Fasting glucose HbA1c Lipid panels Body composition measurements when available Without baseline measurements, it becomes difficult to determine whether metabolic changes are occurring or whether dose adjustments are producing meaningful effects

Untreated PE leads to chronic complications like chronic thromboembolic disease and chronic thromboembolic pulmonary hypertension, which requires long term clinic follow up

In addition, not every patient requires the full therapeutic dose to achieve improvements in glucose control or weight reduction

Additionally, GLP-1 signaling influences calcitonin gene-related peptide (CGRP), a neuropeptide strongly implicated in migraine pathophysiologythe same target that newer migraine-specific medications like erenumab address