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Examination of absolute standardised mean differences for all the seven trials after weighting showed that all absolute values of standardised mean differences were below 0.1 suggesting good balance between the GLP-1 receptor agonist and the SGLT-2 inhibitor groups (see supplementary figure S3 for trial 1 and supplementary figure S4 for trials 2-7)

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Taken together, these results suggest that the vagus nerve is involved in a key GLP-1 signal transduction pathway that modulates locomotor activity in gut microbiota-deficient mice

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In addition, the activation of GLP-1R by exendin-4 increased cAMP accumulation and reduced cytokine production in IELs