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Nevertheless, there is little concordance between the available localization data from immunohistochemistry vs

Efficacy for blood sugar (HbA1c) In clinical trials, metformin reduced HbA1c by 1%-2% or 11-22 mmol/mol and fasting blood glucose (FBG) by 2-3 mmol/L in patients with type 2 diabetes

By acting on brain regions that regulate appetite and reward processing, these medications appear to quiet food-related thoughts, diminish cravings, and help patients regain control over their eating behaviors

[DOI] [PMC free article] [PubMed] [Google Scholar] 3.Tamayo-Trujillo R., Ruiz-Pozo V.A., Cadena-Ullauri S., et al

However, three factors may explain this discrepancy
