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For example, a medication might strongly activate brain GLP-1 receptors for appetite suppression while only partially activating gut receptors that contribute to nausea

Expert Opin Pharmacother (2006) 7:2095105

Important Drawbacks to Consider GLP-1s are not without downsides
rotating injection sites and changing the site for each dose to help prevent skin irritation and scar tissue buildup
After another 1-2 weeks the dose can be increased to 1000 mg twice a day