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Description
But researchers noticed something they were not expecting
The explanation for the discrepancy in the reduction of MACE in patients treated with SGLT2i in DECLARE-TIMI 58 suggests that the benefits of SGLT2i may be more pronounced in patients with a higher risk of cardiovascular disease

GLP-1 medications work by suppressing appetite, sometimes dramatically
There is also a hormonal argument

Effect of a multifactorial intervention on mortality in type 2 diabetes
