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In fibroblast-like rheumatoid arthritis synoviocytes, treatment with lixisenatide inhibited the inflammatory response by downregulating pro-inflammatory cytokines such as TNF, IL-6, and IL-8

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Tirzepatide's 9:1 GIPR bias means it preferentially activates the GIP receptor while engaging GLP-1R at a lower relative potency

However, tirzepatide also imitates a second hormone, called GIP, which, along with reducing appetite, is thought to improve how the body breaks down sugar and fat