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With that framing in place, here's the research context that informs clinical interest in the GLP-1 receptor agonist class: GLP-1 receptor agonists and the insulin/glucagon axis

At the height of semaglutide shortages in 2023, experts from the American Diabetes Association published recommendations around how to prescribe lower doses for patients with diabetes

While the impact of GLP-1 RAs on cardiovascular outcomes has been shown to be directly correlated with the reduction in A1c, these agents exhibit pleiotropic effects [54]

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