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This is a physiological response, not a personal failureit demonstrates why sustainable weight management often requires ongoing pharmaceutical support alongside behavior change

[DOI] [PubMed] [Google Scholar] Ichise M, Harris PE

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Underlying medical conditions: Certain conditions can blunt weight loss responses, including hypothyroidism (a thyroid function test is advisable if not recently checked), Cushing's syndrome or exogenous corticosteroid use, polycystic ovary syndrome (PCOS), and obstructive sleep apnoea (OSA)