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A thoughtful conversation with a healthcare provider helps weigh the benefits, risks, costs, and personal goals before deciding

Researchers modified the original peptide structure to create longer-acting formulations with various strategies: liraglutide (once daily) uses fatty acid albumin-binding, dulaglutide (once weekly) employs an Fc-fusion approach, exenatide extended-release (Bydureon, once weekly) utilises microsphere technology, and semaglutide (once weekly) incorporates fatty acid modifications

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Notably, in healthy human volunteers, acute administration of GLP-1, GLP-1 (9-36amide), or exenatide did not affect blood flow in the mesenteric or renal arteries, excluding splanchnic vasodilatation as a potential mechanism underlying the chronic hypotensive effect of GLP-1 [644]

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