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Medicare drug price negotiation under the Inflation Reduction Act (IRA) represents a positive step toward curbing excessive market monopolies as a result of patent abuse and pricing disparities

Carla Gaggiano and Riccardo Terribili critically revised the manuscript

The treatment cost included GLP-1 RA and metformin drug costs, needle costs, and treatment costs for adverse events

Understanding the mechanisms behind muscle loss and evidence-based protective strategies helps patients and healthcare providers optimize body composition outcomes during GLP-1 therapy

Appetite changes, feeling fuller longer, and eating less often appear in the first few days, weight loss should occur within a couple weeks and builds over time as the dose is increased