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In rats, the LWP-induced GLP-1 secretion further improves glucose tolerance and enhances insulin secretion, an effect that is blocked by pre-administration of the GLP-1R antagonist exendin (939) [306]
Fenfluramine, one of the earliest weight loss drugs, was found over time to be associated with valvular heart disease [48] and was withdrawn from the market by the FDA
Several studies have shown that tirzepatide reduces insulin resistance, improves glycemic control, and lowers inflammatory biomarkers, including C-reactive protein and IL-6 (46, 47)
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