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However, up to 89% of participants taking efinopegdutide experienced gastrointestinal adverse events (mostly nausea, vomiting and diarrhoea) relative to 28% taking placebo and 60% taking liraglutide (86)

Legal and Ethical Considerations: While off-label use of medications is legal and sometimes necessary, healthcare professionals and experts must carefully evaluate the risks and benefits before prescribing medications off-label

And health is not determined by the number on the scale

Its underexploitation in metabolic indications likely reflects disciplinary silos rather than a lack of biological relevance

The existing data is reassuring