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The Journal of Clinical Endocrinology and Metabolism

In the high-response group, tirzepatide was linked to lower posttreatment prevalence of several gastrointestinal symptoms than semaglutide

Expert Consensus: American College of Physicians: GLP-1 receptor agonists should be considered for patients with obesity who have not achieved weight loss goals with lifestyle modifications. Endocrine Society: Semaglutide and tirzepatide represent significant advances in obesity pharmacotherapy and should be considered first-line options. Obesity Medicine Association: The dramatic efficacy of GLP-1 and dual agonist medications has fundamentally changed the treatment landscape for obesity. Real-World Effectiveness: Studies of patients using these medications outside clinical trials show: GLP-1s: Similar to clinical trial results (confirming real-world effectiveness) Older medications: Often less effective in real-world than trials (adherence issues) Patient satisfaction: Highest with GLP-1s Bottom Line: Which Works Best

Dual GLP-1/GIP agonist

While this number must be contextualized against the millions of doses administered, it underscores that quality control issues in compounded products are not hypothetical