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Both of these medications may result in permanent hypothyroidism if they are taken for a long period of time

The switch to anaerobic glycolysis in the ischemic area provided a compensatory substrate switch to overcome the energetic deficit in this region with reduced tissue oxygenation
Greish, K

Sousa MS, Martin P, Johnson MJ, Lind M, Maddocks M, Bullock A, et al

Bupropion causes nausea in roughly 10-15% of users, also most prominently during initiation