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Clinical trials show semaglutide users lose 1015% of body weight over one year at standard doses

A similar safety profile was observed in the SURMOUNT-2 randomized trial of tirzepatide in adults with obesity and T2DM where GIT adverse events were the most frequently reported with no data on neuro or psychiatric adverse events available [15]

A very good example is linagliptin, which is predominantly excreted through the bile rather than through the kidneys