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Norepinephrine reuptake inhibition: Increases metabolic rate (thermogenesis) Enhances fat oxidation Suppresses appetite centrally Increases energy expenditure Also increases heart rate and blood pressure (side effects) 3

Its sympathomimetic effects (BP, HR) raise concern for renal harm in moderate-to-severe CKD

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[27] investigated primary cultures of rat and human thyroid cells to assess the expression and function of GLP-1R in C cells

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